For example, for SF4 it isn't so. And there is a special *.reg file which helps to set half resolution. It will be interesting to test it with V.
For some games it seems that until the OS does not allow half resolution, it is also forbidden in games (It's also interesting to test)
I know that SP4 desktop (not the games) become blurry with half resolution. And this is the main reason that people do not like to use it. But on the other hand, the Internet is full of questions abut MS4 applications scaling issues, which can be solved by using half resolution.